• Hepatic melanomacrophage centers in the arctic cultured fish Cyclopterus lumpus are not indicative of its health state 

      Passantino, Letizia; Corriero, Aldo; Pousis, Christo; Zupa, Rosa; Perillo, Antonella; Superio, Joshua Lustracion; Swain, Jaya Kumari; Foss, Atle; Galindo-Villegas, Jorge; Ventriglia, Gianluca (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-26)
      The lumpfish, Cyclopterus lumpus, holds significant promise as a candidate for large-scale aquaculture production, particularly in its role as a cleaner fish used to manage sea lice infestations in Atlantic salmon Salmo salar farming. Melanomacrophage centers (MMCs) represent polymorphic structures present in the hemolymphopoietic organs of various vertebrates, serving as a widely applicable ...
    • Overexpression of T-bet, GATA-3 and TGF-ß induces IFN-γ, IL-4/13A, and IL-17A expression in Atlantic salmon 

      Slettjord, Tiril Hoffstrøm; Sekkenes, Hege J.; Chi, Heng; Bøgwald, Jarl; Swain, Trilochan; Dalmo, Roy Ambli; Swain, Jaya Kumari (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-20)
      The overexpression of <i>GATA-3, T-bet</i> and <i>TGF-ß</i> may theoretically induce <i>IL-4/A, IFN-γ</i> and <i>IL-17A</i> expression, respectively. Whether this also applies to fish is not yet known. The plasmid vectors encoding reporter gene (RFP)-tagged <i>T-bet, GATA-3</i> and <i>TGF-ß</i> were used as overexpression tools, transfected into cells or injected intramuscularly to monitor the ...
    • Production of sterile Atlantic salmon by germ cell ablation with antisense oligonucleotides 

      Tveiten, Helge; Andersen, Øivind; Swain, Jaya Kumari; Johnsen, Hanne; Mommens, Maren; Slanchev, Krasimir (Journal article; Tidsskriftartikkel, 2023)
      Cultivation of sterile-only fish in aquaculture offers multiple benefits of environmental, economical, and social value. A reliable method for efficient sterilization without affecting fish welfare and performance traits would have significant impact on fish production practices. Here, we demonstrate sterilization of Atlantic salmon embryos by targeting the dead end gene with antisense oligonucleotides. ...
    • Promiscuous T cell epitopes boosts specific IgM immune response against a P0 peptide antigen from sea lice in different teleost species 

      Leal, Yeny; Velazquez, Janet; Hernandez, Liz; Swain, Jaya Kumari; Rodríguez, Alianet Rodríguez; Martínez, Rebeca; García, Claudia; Ramos, Yassel; Estrada, Mario Pablo; Carpio, Yamila (Journal article; Tidsskriftartikkel, 2019-06-11)
      The development of vaccines employing conserved protein antigens, for instance ribosomal protein P0, has as disadvantage the high degree of identity between pathogen and host proteins due to possible induction of tolerance or auto antibodies in the host organism. To overcome this drawback, peptide-based vaccines have been designed with a proved high efficacy. The use of defined peptides as antigens ...